Recent discussions

  • Mayuki Aibiki

    (modified: )

    Dear friends:We are writing for your request of delivering JRC comments on CoSTR draft: antiarrhythmic drugs for cardiac arrest-adult. Please, kindly find our comments attached below.Hiroshi Nonogi, MD, PhD, FAHA, FJCC, FJCAToshikazu Funazaki MD, PhDMayuki Aibiki, MD, PhD Comment:The latest CoSTR draft has dealt with only RCTs including two Japanese studies of small number of OHCAs with shock-resistant VF. We are now raising recent systematic review (SR) including Japanese papers of non-RCTs describing the effects of nifekalant for OHCAs with refractory VF (ref.#3-7 as shown below). Total numbers of patients in such papers were 1532 in ref. #3-5; 317 in ref. #6.7. You should have already known that in the recent SR, there were no differences in ROSC, survival to admission, survival to discharge or neurological outcome in OHCA survivors between amiodarone and nifekalant; but in the comparisons between lidocaine and nifekalant, nifekalant demonstrated a significantly improved survival to admission (p=0.003), whereas no benefits in ROSC, survival to discharge or neurological outcomes. Reference1. Amino M, et al. Journal of cardiovascular pharmacology. 2010; 55: 391-8.2. Igarashi M, et al., Pacing Clin Electrophysiol. 2005;28 Suppl 1: S155-7.3. Harayama N, et al., J Anesth. 2014; 28: 587-92.4. Amino M, et. Al., Journal of cardiovascular pharmacology. 2015; 66: 600-9.5. Tagami T, et al., Resuscitation. 2016; 109: 127-132.6. Shiga T, et. al. Resuscitation. 2010; 81: 47-52.7. Tahara Y, et al., Circ J. 2006; 70: 442-6.8. Chowdhury A, et al., Heart Lung Circ. 2018; 27: 280-290.
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Saul Drajer

    (modified: )

    If amio and lido seem to be almost the same, we'll have to start looking for new drugs! Saul Drajer
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Kurt Anseeuw

    (modified: )

    Is there a difference in outcome in EMS systems where EMS-personnel is trained in using tracheal tube or supraglottic devices and EMS systems without these techniques ?
    In following article:
    CPR: Chest Compression to Ventilation Ratio - EMS delivered (BLS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Kurt Anseeuw

    (modified: )

    Nice work. Is there an effect of different dosing of antiarrhythmic drugs ?
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Jasmeet Soar

    (modified: )

    Thanks for the comments so far. The main change is that amiodarone and lidocaine have equal status in the treatment recommendation. Jasmeet Soar ALS TF Chair
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Jesús López Herce

    (modified: )

    Knowledge gapsThe quality of chest compression and ventilation was not evaluated in any study and these facts could significantly influence the results of CPR
    In following article:
    CPR: Chest Compression to Ventilation Ratio - Bystander - Pediatric (PLS): Systematic Review

    · ILCOR staff · Final CoSTR

  • laurie morrison

    (modified: )

    Nicely done ALS And PLS TF and Heleen and Koen for the interface.
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Emily Montgomery

    (modified: )

    Does this represent a change from 2015 CoSTR? I don't think so.
    In following article:
    Antiarrhythmic drugs for cardiac arrest – Adults (ALS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Jeroen Janssens

    (modified: )

    looking forward to see progress in the gaps.
    In following article:
    CPR : Chest Compression to Ventilation Ratio - Adult (BLS): Systematic Review

    · ILCOR staff · Final CoSTR

  • Joris Spruyt

    (modified: )

    well done
    In following article:
    CPR : Chest Compression to Ventilation Ratio - Adult (BLS): Systematic Review

    · ILCOR staff · Final CoSTR

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