COVID-19 infection risk to rescuers from patients in cardiac arrest: Systematic Review

Conflict of Interest Declaration

The ILCOR Continuous Evidence Evaluation process is guided by a rigorous ILCOR Conflict of Interest policy. The following Task Force members and other authors were recused from the discussion as they declared a conflict of interest: none applicable.

The following Task Force members and other authors declared an intellectual conflict of interest and this was acknowledged and managed by the Task Force Chairs and Conflict of Interest committees: none applicable.

CoSTR Citation

Couper K, Taylor-Phillips S, Grove A, Freeman K, Osokogu O, Court R, Mehrabian A, Morley P, Nolan JP, Soar J, Berg K, Olasveengen T, Wyckoff MH, Greif, R, Singletary N, Castren M, de Caen A, Wang T, Escalante R, Merchant R, Hazinski M, Kloeck D, Heriot G, Neumar R, Perkins GD on behalf of the International Liaison Committee on Resuscitation.

COVID-19 infection risk to rescuers from patients in cardiac arrest.

Consensus on Science with Treatment Recommendations [Internet] Brussels, Belgium: International Liaison Committee on Resuscitation (ILCOR), 2021 February 11. Available from: http://ilcor.org

Methodological Preamble and Link to Published Systematic Review

The continuous evidence evaluation process for the production of Consensus on Science with Treatment Recommendations (CoSTR) started with a systematic review (CRD42020175594) conducted by Warwick Evidence at the University of Warwick with involvement of clinical content experts.{Couper K, Taylor-Phillips S, Grove A, Freeman K, Osokogu O, Court R,

Mehrabian A, Morley PT, Nolan JP, Soar J, Perkins GD. COVID-19 in cardiac arrest

and infection risk to rescuers: A systematic review. Resuscitation. 2020; 151:59-66. https://pubmed.ncbi.nlm.nih.gov/32325096/}

The same search strategy was re-run on January 26, 2021 to update the CoSTR.

PICOST

This review encompassed three review questions.

Research question one

The PEOST (Population, Exposure, Outcome, Study Designs and Timeframe)

Population: Individuals in any setting

Exposure: Delivery of:

1) Chest compressions

2) Defibrillation

3) CPR (all CPR-interventions that include chest compressions)

Outcomes: Generation of aerosols (critical outcome).

Study Designs: Randomized controlled trials (RCTs) and non-randomized studies (non-randomized controlled trials, interrupted time series, controlled before-and-after studies, cohort studies, case reports/series, cadaver studies) are eligible for inclusion. Unpublished studies (e.g., conference abstracts, trial protocols) are excluded.

Timeframe: All years and all languages were included as long as there was an English abstract; unpublished studies (e.g., conference abstracts, trial protocols) were excluded.

Research question two

The PEOST (Population, Exposure, Outcome, Study Designs and Timeframe)

Population: Individuals in any setting wearing any/ no personal protective equipment

Exposure: Delivery of:

1) Chest compressions

2) Defibrillation

3) CPR (all CPR-interventions that include chest compressions)

Outcomes: Transmission of infection (critical outcome).

Study Designs: Randomized controlled trials (RCTs) and non-randomized studies (non-randomized controlled trials, interrupted time series, controlled before-and-after studies, cohort studies, case reports/ series) are eligible for inclusion. Unpublished studies (e.g., conference abstracts, trial protocols) are excluded.

Timeframe: All years and all languages were included as long as there was an English abstract; unpublished studies (e.g., conference abstracts, trial protocols) were excluded.

Research question three

The PICOST (Population, Intervention, Comparator, Outcome, Study Designs and Timeframe)

Population: Individuals delivering chest compressions and/or defibrillation and/ or CPR in any setting

Intervention: Wearing of personal protective equipment

Comparison: Wearing any alternative system of personal protective equipment or no personal protective equipment

Outcomes: Infection with the same organism as patient (critical-9); PPE effectiveness (critical- 7); Quality of CPR (important -5)

Study Designs: Randomized controlled trials (RCTs) and non-randomized studies (non-randomized controlled trials, interrupted time series, controlled before-and-after studies, cohort studies, cadaver studies, simulation studies) are eligible for inclusion. Unpublished studies (e.g., conference abstracts, trial protocols) are excluded.

Timeframe: All years and all languages were included as long as there was an English abstract; unpublished studies (e.g., conference abstracts, trial protocols) were excluded.

PROSPERO Registration CRD42017080475

Original searches were completed on March 24 2020. To reflect the ongoing international impact of the COVID-19 pandemic and rapidly evolving literature, we subsequently updated searches on four occasions (April 30 2020, August 3 2020, October 15 2020, January 26 2021).

In most cases bias was assessed per comparison rather than per outcome, since there were no meaningful differences in bias across outcomes. In cases where differences in risk of bias existed between outcomes, this was noted.

Consensus on Science

Across all research questions and outcomes, heterogeneity in study design, exposures and outcomes precluded meta-analysis.

Research question one

For the critical outcome of aerosol generation, we identified evidence from two case reports (Chalumeau 2005 e29-30, Nam 2017 e2017052) and one cadaver study (Ott 2020 192). These studies evaluated chest compression delivery with performance of airway manoeuvres (Chalumeau 2005 e29-30, Nam 2017 e2017052, Ott 2020 192) and without associated airway manoeuvres (Ott 2020 192). Studies reported the generation of aerosols based on either the transmission of infection or photography of ultraviolet sensitive detergents. No study examined aerosol generation in the context of defibrillation. Overall evidence certainty was rated as very low due to serious risk of bias and serious indirectness.

Research question two

For the critical outcome of transmission of infection, we included one prospective cohort study comprising 1718 healthcare workers (El‐Boghdadly 2020 1437), three retrospective cohort studies comprising 728 healthcare workers,(Loeb 2004 251, Raboud 2010 e10717, Ran 2020 2218) one case-control study comprising 477 healthcare workers,(Liu 2009 52-59), and five case-reports( Chalumeau 2005 e29, Christian 2004 287, Kim 2015 1681, Knapp 2016 48, Nam 2017 e2017052)

Of the five observational studies, four did not report a statistically significant association between CPR-related activities and infection.(Loeb 2004 251; Raboud 2010 e10717, Ran 2020 2218, El‐Boghdadly 2020 1437) A case-control study (Liu 2009 52-59) reported an association between chest compression delivery and SARS infection in healthcare workers (adjusted odds ratio 4.52, 95% confidence interval 1.08-18.81), but the analysis did not adjust for other key potential contacts and there was a significant correlation between chest compressions and tracheal intubation.

Two case reports described transmission of an airborne bacterial infection in cases where CPR was delivered (including ventilation) and PPE was not worn.(Chalumeau 2005 e29, Knapp 2016 48) In three cases, transmission of an airborne viral infection was described, all of which described healthcare workers wearing PPE.( Christian 2004 287, Kim 2015 1681, Nam 2017 e2017052) In one case report, a nurse wearing personal protective equipment who delivered only chest compressions developed infective symptoms following a cardiac arrest, although it is unclear whether the nurse was also present in the room during tracheal intubation and bag-mask ventilation. Delivery of defibrillation was not described in any of the three case reports. Overall evidence certainty was rated as very low due to serious risk of bias and serious indirectness.

Research question three

For the critical outcome of Infection with the same organism as the patient, we found no evidence.

For the critical outcome of PPE effectiveness, we found evidence from one manikin randomized controlled trial enrolling 30 healthcare providers.(Shin 2017 e8308) The study reported differences in the adequacy of protection provided by different mask types during delivery of chest compressions (cup-type 44.9% ± 42.8 v fold-type 93.2% ± 21.7 v valve-type 59.5% ± 41.7, p<0.001), and evidence of reduced protection from a pre-chest compression baseline assessment. Evidence certainty was rated as low, downgraded for serious risk of bias and serious indirectness.

For the important outcome of CPR quality, we included evidence from four randomized controlled manikin trials enrolling 184 participants(Schumacher 2013 33, Shin 2017 e8308, Watson 2008 333, Tian 2020) and one non-randomised manikin study enrolling 48 participants (Serin 2020). The outcome of treatment time was reported in two studies.(Schumacher 2013 33-8, Watson 2008 333-8) In a study of paediatric cardiac arrest, paramedic time to complete four key tasks, including tracheal intubation and intraosseous access, was longer when paramedics wore personal protective equipment (no PPE 261 ± 12 seconds v full face mask 275 ± 9 v hood 286 ± 13, p=0.001).(Schumacher 2013 33-8) In a study of 58 firefighters that compared the effect of wearing different types of gown along with gloves, eye protection and an N95 mask found that not wearing a gown reduced time to first compression (no gown 39 seconds (95% CI 34–43) v standard gown 71 seconds (95% CI 66–77, p < 0.01); v modified gown 59 seconds (95% CI 54–63), p < 0.001). The outcome of chest compression quality was reported in three studies enrolling 158 participants, of which two studies identified differences in CPR quality between types of PPE (Tian 2020, Serin 2020) and one study found no difference in chest compression quality between types of PPE.(Shin 2017 e8308) Evidence certainty was rated as very low, downgraded for very serious risk of bias and serious indirectness.

Treatment Recommendations

We suggest that chest compressions and cardiopulmonary resuscitation have the potential to generate aerosols (weak recommendation, very low certainty evidence).

We suggest that in the current COVID-19 pandemic lay rescuers consider chest compressions and public access defibrillation (good practice statement).

We suggest that in the current COVID-19 pandemic, lay rescuers who are willing, trained and able to do so, consider providing rescue breaths to children in addition to chest compressions (good practice statement).

We suggest that in the current COVID-19 pandemic, healthcare professionals should use personal protective equipment for aerosol generating procedures during resuscitation (weak recommendation, very low certainty evidence).

We suggest it may be reasonable for healthcare providers to consider defibrillation before donning aerosol generating personal protective equipment in situations where the provider assesses the benefits may exceed the risks (good practice statement).

Justification and Evidence to Decision Framework Highlights

• This topic was prioritized by ILCOR based on ongoing international clinical uncertainty regarding the optimum approach regarding the initiation of chest compressions and defibrillation in known or suspected COVID-19 patients.

• ILCOR seeks to provide evidence-based recommendations for implementation by regional and national resuscitation councils. The practical implementation of these recommendations will require regional and national resuscitation councils to consider the values and preferences of their local communities, the prevalence of disease, uptake of vaccination, availability of PPE, training needs of their workforce and infrastructure/resources to provide ongoing care for patients resuscitated from cardiac arrest.

• The WHO describe two modes for transmission of COVID-19 droplet transmission and airborne transmission. WHO reports COVID-19 is primarily transmitted through droplets from either direct contact with the patient or indirectly through contact with surrounding environment. Airborne transmission is also possible during aerosol generating procedures. https://www.who.int/news-room/...

• WHO list cardiopulmonary resuscitation as an aerosol generating procedure.https://apps.who.int/iris/rest/bitstreams/1319378/retrieve-of-sars-cov-2-implications-for-infection-prevention-precautions Cardiopulmonary resuscitation is a complex intervention with several components e.g. ventilation, defibrillation, chest compression, drug administration. The risks and benefits of these procedures vary and were the focus for this review by the International Liaison Committee on Resuscitation.

• This CoSTR complements other guidelines which describe the personal protective equipment that should be worn for aerosol generating procedures. https://apps.who.int/iris/rest/bitstreams/1319378/retrieve-of-sars-cov-2-implications-for-infection-prevention-precautions ; https://www.sccm.org/getattachment/Disaster/SSC-COVID19-Critical-Care-Guidelines.pdf?lang=en-US; https://journals.lww.com/ccmjournal/Abstract/9000/Surviving_Sepsis_Campaign_Guidelines_on_the.95371.aspx

• In the context of chest compressions, aerosol generation is plausible as chest compressions do generate passive ventilation associated with small tidal volumes.(Deakin 2007 53) It also has parallels with chest physiotherapy techniques which are associated with aerosol generation, although in that context the intent is often to induce coughing and aerosol generation.(Simonds 2010 131) Furthermore, the person performing chest compressions is in physical contact with the patient and in close proximity to the airway.

• We did not identify evidence that defibrillation either does or does not generates aerosols. If it occurs the duration of an aerosol generating process would be brief. Furthermore, the use of adhesive pads, when available, means that defibrillation can be delivered without direct contact between the defibrillator operator and patient.

• We acknowledge the risks of confounding as none of the identified studies were able to separate risks related to individual components of a resuscitation attempt (compressions, ventilations, defibrillation) from the resuscitation attempt as a whole. We further note the indirectness of evidence as no included studies reported data on COVID-19 which may have a different transmissibility risk to other infections.

• Outside of the COVID-19 pandemic, each year over 1 million people sustain an out of hospital cardiac arrest around the world. CPR and defibrillation provide these people with the only chance of survival. (Iwami 2020 Resuscitation. 2020 Jul;152:39-49)

• In making recommendations, there is a need to carefully balance the benefit of early treatment with chest compressions and defibrillation (prior to donning personal protective equipment) with the potential harm to the rescuer, their colleagues and the wider community if the rescuer were to be infected with COVID-19.

• In suggesting that lay rescuers consider compression only CPR and public access defibrillation, the writing group noted that the majority of out of hospital cardiac arrests occur in the home where those providing resuscitation are likely to have been in contact with the person requiring resuscitation; that accessibility to personal protective equipment for aerosol generating procedures is likely to be limited; there may be significant harm from delaying potentially lifesaving treatment if resuscitation is deferred until arrival of personnel with suitable personal protective equipment.

• In suggesting that lay rescuers who are willing, trained and able to do so, may wish to consider rescue breaths in addition to chest compressions, the writing group considered that bystander rescuers are frequently those who routinely care for the child. In that case, the risk of the rescuer newly acquiring COVID-19 through provision of rescue breaths is greatly outweighed by improved outcome for children in asphyxial arrest who receive ventilations.

• In suggesting that healthcare professionals should use personal protective equipment for aerosol generating procedures we considered that healthcare professionals would have greater access to PPE, would likely be trained in its use, and may be able to don PPE before arriving at the patient’s side, thus minimizing delays to commencing or continuing resuscitation.

• Given the potential for defibrillation within the first few minutes of cardiac arrest to achieve a sustained return of spontaneous circulation and uncertainty of the likelihood of defibrillation generating an aerosol, we suggest healthcare providers consider the risks versus benefits of attempting defibrillation prior to donning personal protective equipment for aerosol generating procedures.

• The time taken for a team to don personal protective equipment may be up to 5-minutes, although individuals may don equipment in around one-minute(Abrahamson 2006 R3, Watson 2008 333-8). However, once donned we identified evidence that there is a risk of mask slippage during chest compression delivery rendering the protective equipment less effective.

• Feedback received during the initial public commenting provided highlighted the challenges of balancing the risks to those providing resuscitation with the potential benefits for the patient requiring resuscitation. ILCOR seeks to provide evidence based recommendations for implementation by regional and national resuscitation councils. The practical implementation of these recommendations will require regional and national resuscitation councils to consider the values and preferences of their local communities, the prevalence of disease, availability of PPE, training needs of their workforce and infrastructure / resources to provide on-going care for patients resuscitated from cardiac arrest.

• During search updates, we identified one new study eligible for research question one (Ott 2020 192), two new studies eligible for research question two (Ran 2020 2218, El‐Boghdadly 2020 1437)_ and two new studies relevant to research question three (Tian 2020, Serin 2020). We reviewed treatment recommendations in the context of these new data, taking in to account study findings and overall contribution to certainty of evidence. Based on this assessment, we determined that these new data did not support a change to current treatment recommendations.

Knowledge Gaps

No identified study assessed the potential for aerosol generation through delivery of chest compressions and/or defibrillation without associated airway maneuvers.

We encourage further research relating to the risks and benefits of resuscitation interventions in the context of the current COVID-19 pandemic.

Further research should explore the effects of strategies to mitigate the risk of viral transmission during chest compression and defibrillation e.g. use of a surgical mask, oxygen mask, cloth applied to the patients mouth and nose.

Attachments

Et D-Table_120221

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